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March 31, 2016
Sent free to the Editorial Board of Referees and any other interested chemists who request it
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ARKIVOC is an international journal of organic chemistry completely free electronically world wide.
No downloading fees to readers and no page or other charges to authors.

Arkat USA, Inc. is a non profit foundation existing to help chemists throughout the world with special emphasis on international cooperation and developing countries.
Arkivoc manuscript activity / Traffic at arkat-usa.org

MS in Hand Mar 1st, 2016: 67. Received 43; Published 9; Rejected 29. In Hand End of Mar 72;
Manuscripts in Hand Jan 1st, 2016: 65; Received 109; Published 19; Rejected 82.

Access hits, March: 721,891 from 116,432 visitors;
2016 to date: 1,699,157 from 279,137 visitors.

Graphical Abstracts
of Manuscripts Published in Arkivoc During March 2016
Arkivoc 2016 Part (i): Special Issue 'Reviews and Accounts'
Chemistry of 3-carbonyl-2-methyl-4-oxo-4H-1-benzopyrans (16-9449LR) [pp. 111-149]
Chandra Kanta Ghosh and Amarnath Chakraborty
Full Text: PDF (665K)
Ionic liquids as novel media for electrophilic/onium ion chemistry and metal-mediated reactions: a progress summary (16-9490LU) [pp. 150-171]
Kenneth K. Laali
Full Text: PDF (646K)
Arkivoc 2016 Part (iii): General Papers
Efficient synthesis of N-acylbenzotriazoles using tosyl chloride: en route to suberoylanilide hydroxamic acid (SAHA) (16-9459NP) [pp. 161-170]
Khalid A. Agha, Nader E. Abo-Dya, Tarek S. Ibrahim and Eatedal H. Abdel-Aal
Full Text: PDF (115K)
Supplementary Material: PDF (6,227K)
Convenient multicomponent reaction synthesis of novel pyrano[4,3-b]pyran derivatives via a domino reaction under microwave irradiation (16-9398DP) [pp. 171-186]
Jingpeng Mao, Jianqiang Wang, Wenhui Zhang, Ziping Li, Jianlin Zhu and Cheng Guo
Full Text: PDF (743K)
Supplementary Material: PDF (1,991K)
A facile green chemistry approaches towards the synthesis of bis-Schiff bases using ultrasound versus microwave and conventional method without catalyst (16-9464JP) [pp. 187-201]
Wael Abdelgayed Ahmed Arafa and Raafat M. Shaker
Full Text: PDF (166K)
Supplementary Material: PDF (4,111K)
Synthesis of 2-(2-phenylethenyl) substituted 4,5-dihydrofurans by regioselective addition of 1,3-dicarbonyl compounds to dienes promoted by cerium(IV) ammonium nitrate (16-9455ZP) [pp. 202-213]
Mehmet Yilmaz and Asli Ustalar
Full Text: PDF (144K)
Synthesis of novel β-lactams and in vitro evaluation against the human malaria parasite Plasmodium falciparum (16-9465UP) [pp. 214-235]
Margaret A.L. Blackie, Tzu-Shean Feng, Peter J Smith and Kelly Chibale
Full Text: PDF (223K)
A New Synthesis of 5,6-dimetoxy-1,2.3.4-tetrahyronaphthalene-2carboylic acid (16-9487VP) [pp. 236-241]
Ajoy Kumar Banerjee and Kimberly Chinea
Full Text: PDF (142K)
Highly efficient stereoconservative syntheses of new, bifunctional atropisomeric organocatalysts (16-9505YP) [pp. 242-261]
Ferenc Faigl, Zsuzsa Erdélyi, Tamás Holczbauer and Béla Mátravölgyi
Full Text: PDF (433K)
Individual Issues of Arkivoc
The following issues were completed during March 2016:

2016 Part (ii): Commemorative Issue in Honor of Jhillu Singh Yadav on the occasion of his outstanding contributions to organic synthetic chemistry
(Facilitator: Srivari Chandrasekhar; Scientific Editor: Ramaiah Muthyala)
(Issue completed with 16 papers and 249 pages)

No issues were closed during March 2016.
No new issues were initiated during March 2016.
Highly cited papers published in Arkivoc since 2012


Lashgari, N.; Ziarani, G. M. Synthesis of heterocyclic compounds based on isatin through 1, 3-dipolar cycloaddition reactions. Arkivoc 2012, (i), 277-320.

Suresh; Sandhu, J. S. Past, present and future of the Biginelli reaction: a critical perspective. Arkivoc 2012, (i), 66-133.

Abdel-Wahab, B. F.; Khidre, R. E.; Farahat, A. A.; El-Ahl, A. S. 2-Chloroquinoline-3-carbaldehydes: synthesis, reactions and applications. Arkivoc 2012, (i), 211-276.

Pal, R.; Sarkar, T.; Khasnobis, S. Amberlyst-15 in organic synthesis. Arkivoc 2012, (i), 570-609.

Schmidt, A.; Wiechmann, S.; Freese, T. Recent advances in neutral and anionic N-heterocyclic carbene - betaine interconversions. Synthesis, characterization, and applications. Arkivoc 2013, (i), 424-469.

Karami, B.; Eskandari, K.; Khodabakhshi, S. One-pot, three component approach to synthesis of multipart fused heterocyclic compounds: Synthesis of fused pyran-2-ones. Arkivoc 2012, (ix), 76-84.

Popova, E. A.; Trifonov, R. E.; Ostrovskii, V. A. Advances in the synthesis of tetrazoles coordinated to metal ions. Arkivoc 2012, (i), 45-65.

Perez-Fernandez, R.; Goya, P.; Elguero, J. A review of recent progress (2002-2012) on the biological activities of pyrazoles. Arkivoc 2014, (ii), 233-293

Yusubov, M. S.; Svitich, D. Y.; Larkina, M. S.; Zhdankin V. V. Applications of iodonium salts and iodonium ylides as precursors for nucleophilic fluorination in Positron Emission Tomography. Arkivoc 2013, (i), 364-395.

Cai, X.; Xie, B. Recent advances on organocatalysed asymmetric Mannich reactions. Arkivoc 2013, (i), 264-293.

Tucker, A. M.; Grundt, P. The chemistry of tryptanthrin and its derivatives. Arkivoc 2012, (i), 546-569.

The 17th Annual Florida Heterocyclic and Synthetic Conference


The 17th Annual Florida Heterocyclic and Synthetic Conference, FloHet-2016, was held at the University of Florida in Gainesville, from February 28th to March 2nd. Eleven plenary lectures, a short course, 54 invited lectures, 36 posters were presented, and a small exposition was held. The next FloHet Conference will be held at the University of Florida from March 4th to 7th, 2018.

Plenary Lectures
Steven Ley, Cambridge University, UK Katritzky Memorial Lecture
"Machine-Assisted Organic Synthesis"
Aaron Aponick , University of Florida, US
"StackPhos: from Structural Curiosity to Enantioselective Catalysis"
Martin Burke, University of Illinois, USA
"Making Molecular Prosthetics with a Small Molecule Synthesizer"
Naoto Chatani, Osaka University, Japan
"Nickel-Catalyzed Functionalization of C-H Bonds Utilizing a New Chelation System"
Abigail Doyle, Princeton University, USA
"New Directions in Nickel-Catalyzed Cross Coupling"
Sabine Flitsch, University of Manchester, UK
"Enzyme Cascades for the Stereoselective Synthesis of Heterocycles"
Nicholas Meanwell, Bristol-Myers Squibb, USA
"The Discovery and Development of Direct Acting Inhibitors of Hepatitis C Virus"
David Mitchell, Eli Lilly, USA
"Designing and applying practical process synthesis methodologies for aminopyrazoles"
John Porco, Boston University, USA
"Chemical Synthesis and Biological Studies of Antitumor Natural Products"
Richmond Sarpong, UC Berkeley, USA
"Strategies and Tactics for the Synthesis of Complex Alkaloids"
David Williams, Indiana University, USA
"Strategies Toward the Synthesis of Polycyclic Alkaloids"

Short Course
Gordon Gribble, Dartmouth College, USA
A Cook’s Tour of Lithium, Palladium, Magnesium, Gold, and Copper in Heterocyclic Chemistry


We thank our Sponsors, Advertisers and Exhibitors; Advion, BioTools, CEM, EigenChem, IUPAC, J & K, Oakwood Products, Rieke Metals, The Royal Society of Chemistry, SynQuest Laboratories, Synthonix, Thieme Chemistry for their generous support.

ADVION
With over 20 years of mass spectrometry and chemistry expertise, Advion offers the expression family of compact mass spectrometers designed for the chemist. The affordability, small size and ease-of-use make them ideal for use directly at the chemist’s bench, giving immediate answers and informed decisions instead of waiting in line at a central analytical service laboratory.
www.advion.com

BIOTOOLS
BioTools specializes in structure elucidation of chiral molecules. The first company to commercialize VCD (Vibrational Circular Dichroism) and ROA (Raman Optical Activity), BioTools provides instrumentation and services. VCD is the fastest growing technique for determination of absolute configuration of chiral molecules and is used worldwide by all top pharmaceutical companies, regulatory agencies and academia.
www.btools.com

CEM
CEM is a leading global provider of microwave laboratory systems that provide fast, reproducible results in rugged, flexible platforms. The Discover® SP System for sequential synthesis and the MARS 6 for parallel synthesis and scale up offer unmatched versatility with options for automation, peptide synthesis, low-temperature chemistries, gas-addition, and more.
www.cem.com

EIGENCHEM
EigenChem Technologies Inc. provides contract research and contract manufacturing services with a specialization in the synthesis of organic chemicals for pharmaceutical, cosmetic, and nutraceutical industries. We have knowledge and skills at performing complex, multi-step synthesis and delivering solutions for one-of-a-kind chemistry-related problems.
www.eigenchem.com

J & K Scientific
As one of the world’s leading chemical manufacturers, J&K Scientific provides thousands of ultrafine chemicals for research in organic chemistry, analytical chemistry, life science and materials science, as well as a wide range of specialty chemical products for both science and industry.
www.jk-scientific.com

OAKWOOD
Oakwood Products, a manufacturer and distributor, supplies research chemicals to the pharmaceutical, agrochemical and materials research communities. The Oakwood product listing contains over 100,000 items, including many unique building blocks and reactive intermediates.
Please visit us at www.oakwoodchemical.com

RIEKE METALS LLC
Rieke Metals Inc. began in 1991 with its foundation in 40+ years of active metal research. The company sells active Rieke Zinc and Magnesium, Grignard and Organozinc reagents, fine organic chemicals and organic semi-conducting polymers/monomers. Headquartered in Lincoln, Nebraska, the facility personally manufactures over 10,000 research compounds.
www.RiekeMetals.com

SYNQUEST
SynQuest specializes in fluorinated organic and inorganic chemicals, providing a creative and innovative range of building blocks, reagents and compressed and liquefied gases. We offer chemical services designed to expedite your research from conception to pilot quantities.
www.synquestlabs.com

SYNTHONIX
Synthonix specializes in the medicinal chemistry driven design of novel 3-dimensional building blocks. These compounds are designed to allow our customers access to unexplored chemical space. Our team of scientists includes Ph.D., Masters, and Bachelor level chemists. Synthonix is focused on delivering high quality products and exceptional satisfaction to all of our customers. We have a 10,000 square foot research and manufacturing facility located in Wake Forest, North Carolina.
www.synthonix.com

THIEME CHEMISTRY
Thieme Chemistry publishes highly evaluated information about synthetic and general chemistry for professional chemists and advanced students since 1909. Our portfolio includes the well known journals SYNFACTS, SYNLETT and SYNTHESIS, the renowned synthetic methodology reference work Science of Synthesis, RÖMPP, the largest chemical encyclopedia published in German, and monographs.
www.thieme-chemistry.com

Forthcoming Conferences


The 27th European Colloquium on Heterocyclic Chemistry (ECHC 2016);
http://www.ldorganisation.com/v2/produits.php?langue=english&cle_menus=1238916009.

This traditional meeting with a famous history will be held in the beautiful Beurs van Berlage, in the city center of Amsterdam, from July 3 to July 6, 2016. The ECHC2016 covers the field in its full range, from Organic Synthesis, Materials and Catalysis to Chemical Biology and Medicinal Chemistry. We have a great line-up of world renowned speakers.

Future Conferences


The 26th International Society of Heterocyclic Chemistry Congress will be held in Regensburg, Germany, 3 to 8 September 2017.


The 18th Florida Heterocyclic and Synthetic Conference (FloHet-2018) will take place at the University of Florida, Gainesville, 4 to 7 March 2018.

ARKIVOC - Free Journal of Organic Chemistry