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February 2018
Sent free to the Editorial Board of Referees and any other interested chemists who request it
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ARKIVOC is an international journal of organic chemistry completely free electronically world wide.
No downloading fees to readers and no page or other charges to authors.

Arkat USA, Inc. is a non profit foundation existing to help chemists throughout the world with special emphasis on international cooperation and developing countries.
Arkivoc manuscript activity / Traffic at arkat-usa.org

MS in Hand Jan 1st, 2018: 60. Received 46; Published 4; Rejected 21. In Hand End of Jan 81;

Access hits, January: 824,903 from 107,140 visitors;

Future Conferences

FloHet-2018 The 18th Florida Heterocyclic & Synthetic Conference March 4 – 7, 2018

FloHet 2018 will be held at the University of Florida in Gainesville, USA, March 4 – 7, 2018. The conference will include a series of plenary, invited, and contributed lectures on synthetic and heterocyclic chemistry, a short course, plus a poster session, and a small exposition. Registration fees of $300 Student/Postdoctoral, $600 Academic, and $1200 Industrial will include a Welcome Party (March 4), coffee breaks on March 5, 6, and 7, a buffet dinner on Monday, wine reception on Tuesday, and a Farewell Party on Wednesday. Complimentary wine will be served at all evening functions.
Special Academic Package - $1200 one faculty member plus 3 students or postdoctorals.

Plenary lectures will be given by:

Robert Grubbs, The 2018 Katritzky Lecturer, California Institute of Technology, US
Bernhard Breit, University of Freiburg, Germany
Vy Dong, University of California at Irvine, US
Martin Eastgate, Bristol-Myers Squibb, US
Antonio Echavarren, ICIQ – Institut Català d’Investigació Química, Spain
Karl Anker Jørgensen, Aarhus University, Denmark
Dawei Ma, Shanghai institute of Organic Chemistry, Chinese Academy of Sciences, China
Ryan Shenvi, The Scripps Research Institute, US
Masakatsu Shibasaki, The University of Tokyo, Japan
Matthew Sigman, University of Utah, US
Tony Zhang, Eli Lilly and Company

The Short Course will be given by: Nicholas A. Meanwell, Bristol-Myers Squibb, A Synopsis of the Properties and Applications of Heteroaromatic Rings in Medicinal Chemistry

Heteroaromatic rings are important structural elements in marketed drugs and their prominence in the pharmacopeia is a function of their unique physicochemical attributes. The plasticity of heteroaromatic rings that facilitates their deployment in drug design takes advantage of several properties, including H-bond acceptor and H-bond donor capability, electron withdrawing effects, dipole-dipole interactions, pKa, aromaticity and topological presentation of substituents. In this presentation, we will summarize fundamental properties of azole and azine heterocycles and provide a synopsis of how the physicochemical properties of these heteroaromatic rings have been exploited in drug design and discovery campaigns.

We welcome and encourage abstract submission for posters on our Registration site: https://flohet.chem.ufl.edu

Graphical Abstracts
of Manuscripts Published in Arkivoc During January 2018
Arkivoc 2018 Part (ii): A Commemorative Issue in Honor of Prof. Kenneth K. Laali
Synthesis and application of a novel bis-1,2,3-triazole ligand containing a 2,2’-bipyrrolidine core (KL-10320OP) [pp. 280-287]
Stephen E. Motika and Xiaodong Shi
Full Text: PDF (259K)
Supplementary Material: PDF (6,098K)
Arkivoc 2018 Part (iii): General Papers
An alternative stereoselective synthesis of (–)-1-Tetrahydropyrenophorol (18-10316MP) [pp. 103-110]
Mahesh Madala, Balamurali Raman, K.V. Sastry, Sridhar Musulla and Gattu Sridhar
Full Text: PDF (772K)
Supplementary Material: PDF (1,815K)
An efficient synthesis of 3-diethoxyphosphoryl-4-(1H-indol-3-yl)-3,4-dihydrocoumarins: a convenient approach to 3-methylene-4-(indol-3-yl)-3,4-dihydrocoumarins (18-10417UP) [pp. 111-124]
Dariusz Deredas, Henryk Krawczyk and Krzysztof Huben
Full Text: PDF (977K)
Supplementary Material: PDF (8,704K)
Highly diastereoselective synthesis of a novel functionalized benzocyclotrimer (18-10408JP) [pp. 125-134]
Musa Erdogan, Selcuk Essiz, Fabrizio Fabris and Arif Dastan
Full Text: PDF (964K)
Supplementary Material: PDF (1,871K)
Arkivoc 2018 Part (iv): A Commemorative Issue in Honor of Dr. Gordon W. Gribble
A Tribute to Prof. Gordon Gribble (GG-1473UT) [pp. 1-5]
Peter Jacobi
Full Text: PDF (163K)
Individual Issues of Arkivoc
No issues were completed during January 2018.
No issues were closed during January 2018.
No new issues were initiated during January 2018.
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New Members
of the Arkivoc Editorial Board of Referees
Prof. Roberta Ettari

ARKIVOC - Free Journal of Organic Chemistry