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January 31, 2015
Sent free to the Editorial Board of Referees and any other interested chemists who request it
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ARKIVOC is an international journal of organic chemistry completely free electronically world wide.
No downloading fees to readers and no page or other charges to authors.

Arkat USA, Inc. is a non profit foundation existing to help chemists throughout the world with special emphasis on international cooperation and developing countries.
Arkivoc manuscript activity / Traffic at arkat-usa.org

MS in Hand Jan 1st, 2015: 87. Received 33; Published 9; Rejected 32. In Hand End of Jan 79;

Access hits, January: 640,879 from 125,263 visitors;

The 16th Annual Florida Heterocyclic and Synthetic Conference

Eleven plenary lectures, one short course, 52 invited lectures, 50 posters, and a small exposition are planned. A feature of FloHet-2015 will be a series of plenary, invited lectures and a short course on fluorination and flow technology with new examples from the fine chemicals industry. For further information, to submit poster abstracts, and to register: http://www.arkat-usa.org/conferences-flohet-others/

Plenary lectures
Albert Padwa, Emory University, US Katritzky Memorial Lecture
A 50 Year Infatuation/Obsession with 1,3-Dipoles
Huw Davies, Emory University, US
N-Sulfonyltriazoles as Useful Precursors to Donor/Acceptor Carbenes
Veronique Gouverneur, Oxford University, UK
Fluorine Chemistry: from Basic to Clinic
Timothy Jamison, MIT, US
Continuous Flow Multistep Synthesis
Peter Maienfisch, Syngenta, Switzerland
Design and Synthesis of Novel Heterocyclic Compounds with Insecticidal Activity
Christel Menet, Galapagos, Belgium
Triazolopyridines as Selective JAK1 Inhibitors: from Hit Identification to GLPG0634
Tobias Ritter, Harvard University, US
Late-Stage Fluorination for PET Imaging
Paul Scola, BMS, US
Discovery of Asunaprevir (BMS-650032): An Approved NS3 Protease Inhibitor for the Treatment of HCV
Jay Siegel, Tianjin University, PRC
Aromatic Heterocyclic Compounds and Their Metal Complexes
Oliver Thiel, Amgen, US
Chemical Adventures with Small and Large Molecules
Yoshinori Yamamoto, Tohoku University, Japan
p-Conjugated Polycycles and Heterocycles through C-H and X-H Activation across Alkynes

Short Course
Graham Sandford, U. of Durham, UK
Selective Direct Fluorination Strategies: Batch and Flow

The use of organofluorine chemistry, fluorine gas in synthesis (including early failures), techniques for laboratory and manufacturing synthesis (batch and flow) and the current state of the art will be covered.

Invited Lecturers
David Ager - You want a Hydroxy Group Where?
Stellios Arseniyadis - A Useful Synthetic Tool toward Diversely Substituted Heterocycles: Application to Natural Product Synthesis
Natarajan Arumugam - Straightforward Synthesis of Novel Pyrrolo[3,4-b]quinolones via Intramolecular Povarov Reaction
Steven Ballet - Azepinone-constrained Amino Acids in Peptide and Peptidomimetic Design
Uwe Beifuss - 2,3-Dihalo-1-propenes and Related Substrates for the Copper-catalyzed Synthesis of Heterocycles
Uli Bernier - Discovery of Chemicals that Mediate Mosquito Host-Seeking Behavior
Manfred Braun - Selective Potassium Channel Openers with Benzothiadiazine-, Benzothiazole-, and Isothiochromanone- skeletons
Juan R. Del Valle - Synthesis of Beta-strand Orthotics for Peptide Conformational Scanning
Adrian Dobbs - Heterocycles and Rare, Neglected Diseases
Tom Driver - The Development of New Transition-Metal Catalyzed Reactions to Access N-Heterocyles
Laurent El Kaim - Isocyanide based Muticomponent Approaches towards Heterocycles
Craig Francis - Synthesis and Reactivity of the New Pyrazolo[1,5-b] [1,2,4,6]Thiatriazine Ring System
Pedro Gois - B-N Dative Bond: A Useful Tool to Modify Proteins and to Assemble Tumor Targeting Conjugates
Michael Gonzalez - Strategies for Increasing the Sustainability of Organic Chemical Synthesis: A Multi-Component Flow Approach
Uros Groselj - Synthesis and Structures of Reactive Intermediates of Organocatalysis with Diarylprolinol Ethers and Imidazolidinones
Phil Harris - Discovery of the Anti-Cancer Drug Votrient
Malcolm Huestis - Iridium(III)-Catalyzed Benzylic Amine-Directed C-H Sulfonamidation of Arenes with Sulfonyl Azides
Zlatko Janeba - Is 'Planamerism' a Novel Stereochemical Phenomenon?
Oleksandr Kanishchev - Synthesis of SF5-Substituted Heterocycles
Marijan Kocevar - The Potential of 2H-Pyran-2-one Derivatives in Organic Synthesis
Kenneth Laali - New Synthetic Applications for Selectfluor as Reagent for Selective Fluorofunctionalization in Ionic Liquids and as Mediator for Oxidative Halogenation
M. Lakshman - Benzotriazoles via Diboron-Mediated N–OH Deoxygenation of 1-Hydroxybenzotriazoles and Pd-Mediated Cross Coupling
Sven Mangelinckx - The Use of Functionalized N-Sulfinyl Imines for the Asymmetric Synthesis of Heterocyclic β-Amino Acid Derivatives
Vakhid A. Mamedov - Ring Transformation Reactions of Quinoxalinones with "Outside" Group Participation
Viktor Milata - Activated Enolethers in the Synthesis of Heterocycles
AnaMinatti - Development of Aminoheterocyclic Xanthenes as Potent and CNS-Penetrant BACE Inhibitors for the Treatment of Alzheimer’s Disease
JC. Monbaliu - Enabling Technologies and Methods for the Synthesis of Bioorganic Molecules
Thomas J.J. Muller - Dithienothiazines as Novel Heterocyclic Donors – Phenothiazine Congeners Enriched in Electron Density
Till Opatz - Aminocarbanions, Radicals and Other Tools for Making N-Heterocycles
Turan Ozturk - Thienothiophene (TT) and Dithienothiophene (DTT) Heterocycles
Xavier Pannecoucke - Fluoroolefins : from Peptidomimetics to Heterocycles
Norton Peet - Synthesis of Oxazolidinone Antibiotics
Zhonghua Pei - Structure-based Design and Biological Profiling of Potent and Selective Tetrahydroindazole ITK Inhibitors
Victor Pike - Synthesis and Reactivity of the New Pyrazolo[1,5-b]thiatriazine Ring System
Reuben D. Rieke - New Synthetic Methods Using Highly Reactive Metals
Floris Rutjes - Organocatalytic Approaches to Biologically Relevant Heterocycles
Jack Ryan - Dipolar Cycloaddition Reactions of a Non-stabilised Azomethine Ylide with Phthalic Anhydrides and Other Unusual Dipolarophiles
Benjamin Sherry - Development of an Efficient Synthetic Route for HIV NNRTI Doravirine
Kourosch Abbaspour Tehrani - Lewis Acid Mediated Alkynylations of Chlorinated N-Alkyl Imines and their Application for the Synthesis of Azaheterocycles
Johan Van der Eycken - A Modular Approach to Chiral Imidates: a New Class of Nitrogen-based Chiral Ligands as Tools for Medicinal Chemistry
Erik V. Van der Eycken - Cationic Gold-Catalyzed Heteroannulations
Daniel Vegh - Synthesis of Highly Fluorinated 3,4-Substituted-1-benzo[b]Thiophene and Benzo[1,2-b;4,5-b']dithiophene Derivatives as Potentially Biologically Active Compounds and Novel Opto-electronic Materials
Stephane Vincent - Synthesis of Fluorinated exo-Glycals and Furans Designed to Inhibit Bacterial Enzymes
Mary Watson - Enantioselective, Copper-Catalyzed Alkynylation of Oxocarbenium and Iminium Ions
Craig M. Williams - Natural Products from the Australian Rainforest
Chris Willis - Challenges in Natural Product Synthesis
Larry Yet - Tailoring Heterocyclic Chemistry Research for Undergraduate Students

FloHet-2015 SPONSORS, EXHIBITORS, and ADVERTISERS

ADVION
With over 20 years of mass spectrometry and chemistry expertise, Advion offers the expression family of compact mass spectrometers designed for the chemist. The affordability, small size and ease-of-use make them ideal for use directly at the chemist’s bench, giving immediate answers and informed decisions instead of waiting in line at a central analytical service laboratory. www.advion.com

CEM
CEM is a leading global provider of microwave laboratory systems that provide fast, reproducible results in rugged, flexible platforms. The Discover® SP System for sequential synthesis and the MARS 6 for parallel synthesis and scale up offer unmatched versatility with options for automation, peptide synthesis, low-temperature chemistries, gas-addition, and more. www.cem.com

OAKWOOD
Oakwood Products, a manufacturer and distributor, supplies research chemicals to the pharmaceutical, agrochemical and materials research communities. The Oakwood product listing contains over 100,000 items, including many unique building blocks and reactive intermediates. Please visit us at www.oakwoodchemical.com

RIEKE METALS LLC
Rieke Metals Inc. began in 1991 with its foundation in 40+ years of active metal research. The company sells active Rieke Zinc and Magnesium, Grignard and Organozinc reagents, fine organic chemicals and organic semi-conducting polymers/monomers. Headquartered in Lincoln, Nebraska, the facility personally manufactures over 10,000 research compounds. www.RiekeMetals.com

SIGMA-ALDRICH
Sigma-Aldrich is a leading Life Science & High Technology company whose biochemical, organic chemical products, kits & services are used in scientific research, including genomic & proteomic research, biotechnology, pharmaceutical development, the diagnosis of disease & as key components in pharmaceutical, diagnostics & high technology manufacturing. We are committed to Enabling Science to Improve the Quality of Life. www.sigmaaldrich.com

STREM
Strem Chemicals, an employee-owned company, established in 1964 manufactures and markets over 4,000 metals, inorganics and organometallics for research and development, including metal catalysts, ligands and biocatalysts for organic synthesis, MOCVD/ALD precursors, bubblers and nanomaterials, for use in pharmaceutical, microelectronics, chemical and petrochemical industries. Custom synthesis services are also provided. cGMP manufacturing is also available. www.strem.com

SYNQUEST
SynQuest specializes in fluorinated organic and inorganic chemicals, providing a creative and innovative range of building blocks, reagents and compressed and liquefied gases. We offer chemical services designed to expedite your research from conception to pilot quantities. www.synquestlabs.com

SYNTHONIX
Synthonix specializes in the medicinal chemistry driven design of novel 3-dimensional building blocks. These compounds are designed to allow our customers access to unexplored chemical space. Our team of scientists includes Ph.D., Masters, and Bachelor level chemists. Synthonix is focused on delivering high quality products and exceptional satisfaction to all of our customers. We have a 10,000 square foot research and manufacturing facility located in Wake Forest, North Carolina. www.synthonix.com

THIEME CHEMISTRY
Thieme Chemistry publishes highly evaluated information about synthetic and general chemistry for professional chemists and advanced students since 1909. Our portfolio includes the well known journals SYNFACTS, SYNLETT and SYNTHESIS, the renowned synthetic methodology reference work Science of Synthesis, RÖMPP, the largest chemical encyclopedia published in German, and monographs. www.thieme-chemistry.com

Graphical Abstracts
of Manuscripts Published in Arkivoc During January 2015
Arkivoc 2015 Part (i): Special Issue 'Reviews and Accounts'
Reactions of fused pyrrole-2,3-diones with binucleophiles (15-8889LU) [pp. 48-69]
Valeriya Vladislavovna Konovalova, Yurii Vladimirovich Shklyaev and Andrey Nikolaevich Maslivets
Full Text: PDF (672K)
Alumina sulfuric acid (ASA), tungstate sulfuric acid (TSA), molybdate sulfuric acid (MSA) and xanthan sulfuric acid (XSA) as solid and heterogeneous catalysts in green organic synthesis: a review (15-8894LR) [pp. 70-96]
Rajesh H. Vekariya and Hitesh D. Patel
Full Text: PDF (516K)
1,4-Dinitro-1H-imidazoles (15-8815LR) [pp. 97-135]
Jerzy Wiktor Suwiński
Full Text: PDF (424K)
Cellulose sulfuric acid (CSA) and starch sulfuric acid (SSA) as solid and heterogeneous catalysts in green organic synthesis: recent advances (15-8975LR) [pp. 136-159]
Rajesh H. Vekariya and Hitesh D. Patel
Full Text: PDF (579K)
1,3-Dipolar cycloaddition reactions of azomethine ylides with aromatic dipolarophiles (15-8928LR) [pp. 160-183]
John H. Ryan
Full Text: PDF (358K)
Arkivoc 2015 Part (ii): A Commemorative Issue in Honor of Prof. Jürgen Martens
Highly flexible synthesis of indenylethylamines as ligand precursors for titanium complexes (JM-8859ZP) [pp. 76-92]
Jan H. Ross, Stefan H. Rohjans, Marc Schmidtmann and Sven Doye
Full Text: PDF (421K)
Supplementary Material: PDF (2,642K)
Arkivoc 2015 Part (iii): A Commemorative Issue in Honor of Prof. Michael Orfanopoulos
The low Kenol values of β-sulfonyl-substituted amides (MO-8927SP) [pp. 18-37]
Ahmad Basheer,Masaaki Mishima and Zvi Rappoport
Full Text: PDF (396K)
Supplementary Material: PDF (1,680K)
Reduction of quinolines to 1,2,3,4-tetrahydroquinolines with hydrosilanes/ethanol catalyzed by TiO2-supported gold nanoparticles under solvent free conditions (MO-8955SP) [pp. 38-51]
Anastasia Louka, Charis Gryparis and Manolis Stratakis
Full Text: PDF (196K)
Supplementary Material: PDF (1,830K)
Arkivoc 2015 Part (v): General Papers
Synthesis of tetramethoxy-(tetra-hydrazinecarboxamide) cyclophanes with unexpected conformation and investigation of their solution-phase recognition of chiral carboxylic guests using time-of-flight and tandem mass spectrometry (15-8875NP) [pp. 1-19]
Hany F. Nour, Agnieszka Golon, Tamer El Malah and Nikolai Kuhnert
Full Text: PDF (928K)
Supplementary Material: PDF (6,272K)
Individual Issues of Arkivoc
No issues were completed during January 2015.
The following issues were closed during January 2015:

2014 Part (vi): General Papers
The following new issues were initiated during January 2015:

2015 Part (v): General Papers
CODESSA III

In collaboration with the Katritzky group at the University of Florida, CODESSA III is a state-of-the art QSAR/QSPR program that works directly with Semichem’s AMPAC to generate predictive models from quantum chemical, electrostatic and topological descriptors. If you are a past user of CODESSA, this completely rewritten product will blow you away! Every aspect of this product has been modernized and improved. Please visit www.semichem.com/codessa for details.

To Announce and Advertise in Arkivoc or at FloHet

For details of opportunities on web site, or in Arkivoc, this newsletter, or our conference manual, contact Eric Scriven - Efvs1@aol.com.

ARKIVOC - Free Journal of Organic Chemistry