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June 30, 2016
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ARKIVOC is an international journal of organic chemistry completely free electronically world wide.
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Arkivoc manuscript activity / Traffic at arkat-usa.org

MS in Hand Jun 1st, 2016: 75. Received 60; Published 20; Rejected 34. In Hand End of Jun 81;
Manuscripts in Hand Jan 1st, 2016: 65; Received 245; Published 61; Rejected 166.

Access hits, June: 96,197 from 14,970 visitors;
2016 to date: 3,136,485 from 485,613 visitors.

Graphical Abstracts
of Manuscripts Published in Arkivoc During June 2016
Arkivoc 2016 Part (i): Special Issue 'Reviews and Accounts'
New heteroatom-rich ring systems from N,N-dialkyl-N’-chlorosulfonyl chloroformamidines (16-9629LU) [pp. 212-275]
Craig L. Francis
Full Text: PDF (789K)
The [5+5] route to the phenanthrene skeleton (16-9611LU) [pp. 276-306]
James W. Herndon and Bishnu Dhakal
Full Text: PDF (420K)
Arkivoc 2016 Part (iv): General Papers
Liquid-phase synthesis of 4-vinyl-1H-1,2,3-triazoles based on polyethylene glycol supported but-3-ynyl sulfonate (16-9491UP) [pp. 152-160]
Zhe Wang, Li-Li Chen, Xue-Chun Mao, Shou-Ri Sheng and Xiao-Ling Liu
Full Text: PDF (607K)
Supplementary Material: PDF (760K)
Toward accessible 3H-Pyrroles (16-9483IP) [pp. 161-171]
Boris A. Trofimov, Marina Yu. Dvorko, Dmitrii A. Shabalin and Elena Yu. Schmidt
Full Text: PDF (712K)
Supplementary Material: PDF (882K)
Enantioselective synthesis of the side-chain acid of homoharringtonine and harringtonine from the same γ-butyrolactone intermediate (16-9388YP) [pp. 172-183]
Moran Sun, Yinchao Li, Xiufang Shi, Changling Niu and Hua Yang
Full Text: PDF (811K)
Supplementary Material: PDF (1,923K)
A facile one-pot synthesis of novel 1-substituted 2-(8-hydroxyquinolin-5-yl)-1,5,6,7-tetrahydro-6,6-dimethyl- 4H-indol-4-one derivatives (16-9602OP) [pp. 184-192]
Shawkat Abdel-Mohsen and Talaat El-Emary
Full Text: PDF (98K)
A new synthetic method of 1β- and 2β-hydroxyprovitamin D3, the precursor of the 1β- and 2β-hydroxyvitamin D3 (16-9598NP) [pp. 193-203]
Bin Sun, Can Jin and Weike Su
Full Text: PDF (251K)
A new route towards dithienoquinazoline and benzo[f]thieno[3,2-h]quinazoline systems using Pd-catalyzed intramolecular cyclization under microwave irradiation (16-9623JP) [pp. 204-216]
Egor V. Verbitskiy, Gennady L. Rusinov, Oleg N. Chupakhin and Valery N. Charushin
Full Text: PDF (885K)
Supplementary Material: PDF (918K)
Epoxide ring-opening approach to the synthesis of diverse trisubstituted cyclopentanes (16-9520NP) [pp. 217-226]
Evgeni A. Larin and Yuri M. Atroshchenko
Full Text: PDF (612K)
Supplementary Material: PDF (3,630K)
Cascade Michael-Aldol reaction: efficient annulation of sulfonamide chalcones into novel cyclohexenones under solvent-free conditions (16-9488GP) [pp. 227-245]
Nikita R. Agrawal, Sandeep P. Bahekar, Abhijeet R. Agrawal, Prashant B. Sarode and Hemant S. Chandak
Full Text: PDF (811K)
Supplementary Material: PDF (7,548K)
Synthesis of Tröger’s base bis(α-aminophosphonate) derivatives (16-9563ZP) [pp. 246-260]
Bhaskar Reddy Manda, Gal Reddy Potuganti and Manjula Alla
Full Text: PDF (845K)
Supplementary Material: PDF (883K)
Sulfonimidation via ring-opening of 2-oxazolines with acidic sulfonimide nucleophiles (16-9609UP) [pp. 261-276]
David A. Gutierrez, Dayton R. Dean, Candace M. Laxamana, Madyson Migliozzi-Smith, Connor J. O’Brien, Claire L. O’Neill and Jie Jack Li
Full Text: PDF (243K)
Supplementary Material: PDF (2,938K)
Multicomponent hot-water synthesis of 7-unsubstituted 4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidines and their antimicrobial and antifungal activity (16-9610VP) [pp. 277-287]
Sergey A. Komykhov, Irina G. Tkachenko, Vladimir I. Musatov, Mikhail V. Diachkov, Valentin A. Chebanov and Sergey M. Desenko
Full Text: PDF (587K)
Supplementary Material: PDF (1,156K)
Synthesis of a 7-aminomethylindole and related bis-indole derivatives (16-9587YP) [pp. 288-295]
Hakan Kandemir, Ibrahim F. Sengul, Naresh Kumar and David StC. Black
Full Text: PDF (219K)
A facile trifluoromethylthiolation of 3-chloro-1H-inden-1-ones employing AgSCF3 and KI (16-9606ZP) [pp. 296-305]
Biao Dong, Xiaofei Zhang, Ruiling Liu and Chunhao Yang
Full Text: PDF (683K)
Supplementary Material: PDF (2,995K)
Synthesis of aryl substituted indanones and indenes via a highly efficient ligand-free palladium-catalyzed Suzuki coupling process (16-9627UP) [pp. 306-327]
Yuming Song, Yamei Xie, Minjian Chen, Jingping Qu, Hongfan Hu, Xiaomei Lang, Shan Xue, Yin Ran and Shixuan Xinb*
Full Text: PDF (951K)
Supplementary Material: PDF (4,964K)
Molecular diversity of four–component synthesis of pyrazole based pyrido[2,3-d]pyrimidine-diones in water: a green synthesis (16-9603IP) [pp. 328-338]
Mansoureh Daraie and Majid M. Heravi
Full Text: PDF (220K)
Supplementary Material: PDF (212K)
Arkivoc 2017 Part (ii): A Commemorative Issue in Honor of Prof. Jacek Młochowski
A tribute to Prof. Jacek Młochowski (MJ-1469UT) [pp. 1-6]
Elżbieta Wojaczyńska
Full Text: PDF (217K)
The Niementowski reaction of anthranilic acid with ethyl acetoacetate revisited: a new access to pyrano[3,2-c]quinoline-2,5-dione (MJ-9584UP) [pp. 7-11]
Yevgen M Poronik, Jan Klajn, Wioleta Borzęcka and Daniel T Gryko
Full Text: PDF (214K)
Supplementary Material: PDF (517K)
Synthetic utility of metal catalyzed hydrogen peroxide oxidation of C-H, C-C and C=C bonds in alkanes, arenes and alkenes: Recent advances (MJ-9578UR) [pp. 12-58]
Halina Wójtowicz-Młochowska
Full Text: PDF (630K)
Application of diethyl ethynephosphonate for the synthesis of 3-phosphonylated β-lactams via Kinugasa reaction (MJ-9660UP) [pp. 59-67]
Marcin K. Kowalski, Grzegorz Mlostoń, Emilia Obijalska and Heinz Heimgartner
Full Text: PDF (248K)
Individual Issues of Arkivoc
The following issues were completed during June 2016:

2016 Part (iii): General Papers
(Issue completed with 30 papers and 386 pages)

The following issues were closed during June 2016:

2016 Part (iv): General Papers
The following new issues were initiated during June 2016:

2016 Part (v): General Papers
2017 Part (iii): Commemorative Issue in Honor of Prof. Oleg A. Rakitin on the occasion of his 65th anniversary
(Facilitator: Panayiotis A. Koutentis; Scientific Editor: Jacques Royer)

The 17th Annual Florida Heterocyclic and Synthetic Conference

The 17th Annual Florida Heterocyclic and Synthetic Conference, FloHet-2016, was held at the University of Florida in Gainesville, from February 28th to March 2nd. Eleven plenary lectures, a short course, 54 invited lectures, 36 posters were presented, and a small exposition was held. The next FloHet Conference will be held at the University of Florida from March 4th to 7th, 2018.

Plenary Lectures
Steven Ley, Cambridge University, UK Katritzky Memorial Lecture
"Machine-Assisted Organic Synthesis"
Aaron Aponick , University of Florida, US
"StackPhos: from Structural Curiosity to Enantioselective Catalysis"
Martin Burke, University of Illinois, USA
"Making Molecular Prosthetics with a Small Molecule Synthesizer"
Naoto Chatani, Osaka University, Japan
"Nickel-Catalyzed Functionalization of C-H Bonds Utilizing a New Chelation System"
Abigail Doyle, Princeton University, USA
"New Directions in Nickel-Catalyzed Cross Coupling"
Sabine Flitsch, University of Manchester, UK
"Enzyme Cascades for the Stereoselective Synthesis of Heterocycles"
Nicholas Meanwell, Bristol-Myers Squibb, USA
"The Discovery and Development of Direct Acting Inhibitors of Hepatitis C Virus"
David Mitchell, Eli Lilly, USA
"Designing and applying practical process synthesis methodologies for aminopyrazoles"
John Porco, Boston University, USA
"Chemical Synthesis and Biological Studies of Antitumor Natural Products"
Richmond Sarpong, UC Berkeley, USA
"Strategies and Tactics for the Synthesis of Complex Alkaloids"
David Williams, Indiana University, USA
"Strategies Toward the Synthesis of Polycyclic Alkaloids"

Short Course
Gordon Gribble, Dartmouth College, USA
A Cook’s Tour of Lithium, Palladium, Magnesium, Gold, and Copper in Heterocyclic Chemistry

We thank our Sponsors, Advertisers and Exhibitors; Advion, BioTools, CEM, EigenChem, IUPAC, J & K, Oakwood Products, Rieke Metals, The Royal Society of Chemistry, SynQuest Laboratories, Synthonix, Thieme Chemistry for their generous support.

With over 20 years of mass spectrometry and chemistry expertise, Advion offers the expression family of compact mass spectrometers designed for the chemist. The affordability, small size and ease-of-use make them ideal for use directly at the chemist’s bench, giving immediate answers and informed decisions instead of waiting in line at a central analytical service laboratory.

The Alachua County Visitors and Convention Bureau "Visit Gainesville" is the source for planning a visit to Gainesville. They provide support for this conference through the Tourist Development Conference Grant, Fall 2015.

BioTools specializes in structure elucidation of chiral molecules. The first company to commercialize VCD (Vibrational Circular Dichroism) and ROA (Raman Optical Activity), BioTools provides instrumentation and services. VCD is the fastest growing technique for determination of absolute configuration of chiral molecules and is used worldwide by all top pharmaceutical companies, regulatory agencies and academia.

CEM is a leading global provider of microwave laboratory systems that provide fast, reproducible results in rugged, flexible platforms. The Discover® SP System for sequential synthesis and the MARS 6 for parallel synthesis and scale up offer unmatched versatility with options for automation, peptide synthesis, low-temperature chemistries, gas-addition, and more.

EigenChem Technologies Inc. provides contract research and contract manufacturing services with a specialization in the synthesis of organic chemicals for pharmaceutical, cosmetic, and nutraceutical industries. We have knowledge and skills at performing complex, multi-step synthesis and delivering solutions for one-of-a-kind chemistry-related problems.

J & K Scientific
As one of the world’s leading chemical manufacturers, J&K Scientific provides thousands of ultrafine chemicals for research in organic chemistry, analytical chemistry, life science and materials science, as well as a wide range of specialty chemical products for both science and industry.

Oakwood Products, a manufacturer and distributor, supplies research chemicals to the pharmaceutical, agrochemical and materials research communities. The Oakwood product listing contains over 100,000 items, including many unique building blocks and reactive intermediates.
Please visit us at www.oakwoodchemical.com

Rieke Metals Inc. began in 1991 with its foundation in 40+ years of active metal research. The company sells active Rieke Zinc and Magnesium, Grignard and Organozinc reagents, fine organic chemicals and organic semi-conducting polymers/monomers. Headquartered in Lincoln, Nebraska, the facility personally manufactures over 10,000 research compounds.

SynQuest specializes in fluorinated organic and inorganic chemicals, providing a creative and innovative range of building blocks, reagents and compressed and liquefied gases. We offer chemical services designed to expedite your research from conception to pilot quantities.

Synthonix specializes in the medicinal chemistry driven design of novel 3-dimensional building blocks. These compounds are designed to allow our customers access to unexplored chemical space. Our team of scientists includes Ph.D., Masters, and Bachelor level chemists. Synthonix is focused on delivering high quality products and exceptional satisfaction to all of our customers. We have a 10,000 square foot research and manufacturing facility located in Wake Forest, North Carolina.

Thieme Chemistry publishes highly evaluated information about synthetic and general chemistry for professional chemists and advanced students since 1909. Our portfolio includes the well known journals SYNFACTS, SYNLETT and SYNTHESIS, the renowned synthetic methodology reference work Science of Synthesis, RÖMPP, the largest chemical encyclopedia published in German, and monographs.

Highly cited papers published in Arkivoc since 2013

Schmidt, A.; Wiechmann, S.; Freese, T. Recent advances in neutral and anionic N-heterocyclic carbene - betaine interconversions. Synthesis, characterization, and applications. Arkivoc 2013, (i), 424-469.

Perez-Fernandez, R.; Goya, P.; Elguero, J. A review of recent progress (2002-2012) on the biological activities of pyrazoles. Arkivoc 2014, (ii), 233-293.

Yusubov, M. S.; Svitich, D. Y.; Larkina, M. S.; Zhdankin, V. V. Applications of iodonium salts and iodonium ylides as precursors for nucleophilic fluorination in Positron Emission Tomography. Arkivoc 2013, (i), 364-395.

Cai, X.; Xie, B. Recent advances on organocatalysed asymmetric Mannich reactions. Arkivoc 2013, (i), 264-293.

Lopez-Ruiz, H.; Emilio de la Cerda-Pedro, J.; Rojas-Lima, S.; Perez-Perez, I.; Viridiana Rodriguez-Sanchez, B.; Santillan, R.; Coreno, O. Cuprous oxide on charcoal-catalyzed ligand-free synthesis of 1,4-disubstituted 1,2,3-triazoles via click chemistry. Arkivoc 2013, (iii), 139-164.

Ansari, A. A.; Lahiri, R.; Vankar, Y. D. The carbon-Ferrier rearrangement: an approach towards the synthesis of C-glycosides. Arkivoc 2013, (ii), 316-362.

Liu, Y. Recent advances on diversity oriented heterocycle synthesis via multicomponent tandem reactions based on A(3) coupling. Arkivoc 2014, (i), 1-20.

Miyata, O.; Miyoshi, T.; Ueda, M. Umpolung reactions at the alpha-carbon position of carbonyl compounds. Arkivoc 2013, (ii), 60-81.

Cai, X.; Xie, B. Recent advances in nickel-catalyzed C-H bond functionalized reactions. Arkivoc 2015, (i), 184-211.

Ali, T. E. Synthetic methods of cyclic alpha-aminophosphonic acids and their esters. Arkivoc 2014, (i), 21-91.

Rubiales, G.; Alonso, C.; Martinez de Marigorta, E.; Palacios, F. Nucleophilic trifluoromethylation of carbonyl compounds and derivatives. Arkivoc 2014, (ii), 362-405.

Ziarani, G. M.; Gholamzadeh, P.; Lashgari, N.; Hajiabbasi, P. Oxindole as starting material in organic synthesis. Arkivoc 2013, (i), 470-535.

Forthcoming Conferences

15th Belgian Organic Synthesis Symposium
July 10-15, 2016 - Antwerp, Belgium

The conference will cover a broad range of timely subjects in the field of organic chemistry. One of the major aims of the BOSS symposia has always been to give young chemists the possibility to attend a high level conference at a reasonable cost, instead of only addressing a small group of highly specialised chemists.

Future Conferences

The 26th International Society of Heterocyclic Chemistry Congress will be held in Regensburg, Germany, 3 to 8 September 2017.

The 18th Florida Heterocyclic and Synthetic Conference (FloHet-2018) will take place at the University of Florida, Gainesville, 4 to 7 March 2018.

New Members
of the Arkivoc Editorial Board of Referees
Dr.. Titu Devamani
United States

ARKIVOC - Free Journal of Organic Chemistry