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COURSES/LECTURES/POSTERS
Heterocyclic and Synthetic Short Courses
John A. Joule, The University of Manchester, UK
Indoles - New Reactions and Synthesis
Gordon W. Gribble, Dartmouth College, USA
Applications of Lithium, Palladium, Magnesium, Gold, and Copper in Heterocyclic Chemistry
Christian V. Stevens, Ghent University, Belgium
Opportunities for Microflow Technology
Pierre Woehl, Corning European Technology Center, France
Physico-chemical / Engineering Aspects of Flow Chemistry
The four courses together aim to provide an overview of important aspects of current Heterocyclic, Synthetic, and Flow Chemistry suitable for attendees from both industry and academia. Each short course alone should serve as an introduction or refresher to the particular topic. A Course Manual will be provided that contains copies of lecture slides and references.
Invited Lecturers
Ten sessions of invited lectures will be presented, three of which will run in parallel with the short courses.
Invited Lecturers confirmed to date:
David Ager, DSM, US
I need it now: On demand synthesis
Fredrik Almqvist, Umea University, Sweden
Design and Synthesis of Ring-fused 2-Pyridones and Applications in Chemical Biology
Abdullah M. Asiri, KAU, Jeddah, Saudi Arabia
TBA
Pierre Audebert, ENS Cachan, France
New tetrazines with specific physicochemical properties. Synthesis, electrochemistry and fluorescence
Urs Brandli, Dottikon Exclusive Synthesis AG, Switzerland
Hazardous Reactions - a Useful Technology for Efficient Manufacturing of Various Heterocyclic Compounds
Jean-Francois Briere, CNRS, Rouen, France
Organocatalyzed Synthesis of Heterocycles
Martin Cohen, Cytec Industries, US
Flow Processes in Specialty Chemicals Manufacture
Nicholas Cosford, Sanford-Burnham Medical Research Institute, US
Microreactor-based Flow Synthesis of Drug-like Heterocyclic Compounds
Jon Dallimore, Syngenta, UK
Synthesis Of Sulfonyl Isoxazoline Herbicides
Ferenc Darvas, ThalesNano, Inc., Hungary
Accessing Novel Chemical Space Through High Temperature Flash Synthesis
Mary Doyle, Sigma-Aldrich, US
Introduction of New Specialty Chemicals: From Micro to Production Scale
Apurba Dutta, University of Kansas, US
Synthesis and Structure-Activity Relationship Studies of the Cytotoxic Anhydrophytoshingosine Jaspine B
El Sayed H. El Ashry, Alexandria University, Egypt
Heterocycles from Carbohydrates Precursors
Stefan France, Georgia Tech., US
TBA
Craig Francis, CSIRO, Melbourne, Australia
Novel Heteroatom-Rich Ring Systems from N,N-Dialkyl-N' Chlorosulfonyl Chloroformamidines
Manuel Francisco, EXXON, US
Syntheses of Alkylated Aromatic Model Compounds To Facilitate Mass Spectral Characterization of Heavy Oils, Resids, and Bitumens
Ferenc Fulop, University of Szeged, Hungary
Heterocycles from cyclic -amino acids
Jim Gleason, McGill University, Canada
Hybridizing Natural Products for Cancer Treatment
Janet Gunzner-Toste, Genentech, US
Discovery of Selective & Efficacious B-Raf Inhibitors
Peter Guzzo, AMRI, NY, USA
Design and Synthesis of Heterocyclic Serotonin Receptor Modulators
Michael Harmata, University of Missouri-Columbia, US
Something Old, Something New, Something Borrowed, Something Benzothiazine
Dominique Hebrault, Mettler-Toledo, US
Enhanced Development and Control of Continuous Processes using Real Time In Situ FTIR Analytics
Maged Henary, Georgia State University, US
Synthesis and In Vivo Imaging Properties of Novel Zwitterionic Near-Infrared Fluorescent Cyanine Dyes
Michel Journet, Merck, US
Flow Chemistry For Greener, More Efficient Processes
Michael J. Karney, CEM Corporation, US
Versatility in Microwave Assisted Organic Synthesis
Fahmida Khan, N.I.T., Chhatisgarh, India
Synthesis and analytical Review of Hydroxamic Acids for Separation Science and Nuclear Fuel Reprocessing
Kristof Kranjc, University of Ljubljana, Slovenia
Regio- and Stereoselectivity of Cycloadditions of 2H-Pyran-2-one Derivatives
Margus Lopp, Tallinn University of Technology, Estonia
Diastereoselective multicomponent cascade reaction leading to heterobicyclic heptanes
Scott May, Eli Lilly and Company, US
Rapid Development and Scale Up of a 1H-4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors
Adriaan Minnaard, University of Groningen, Netherlands
Catalytic Asymmetric Addition of Grignard Reagents to Ketones
Jean-Christophe Monbaliu, Ghent University, Belgium
Development of continuous processes under green and safe conditions
Kent Nielsen, University of Southern Denmark, Denmark
Supramolecular Polymers Based on Tetrathiafulvalenes
Michael North, Newcastle University, UK
Synthesis of heterocycles from epoxides and heterocumulenes catalysed by aluminium(salen) complexes
Grant Norton, Washington State University, US
Nanosprings™: A High Surface Area Support for Enzyme-Based Continuous Flow Reactors
Daniela Carmen Oniciu, Cerenis Therapeutics Holding, France
Novel Heterocyclic Non-Nucleotide HDL Modulators via the P2Y13 Receptor, an Unexplored Target in the Treatment of Cardiovascular Disease
Donald Pinto, Bristol-Myers Squibb, US
The Discovery of apixaban (Eliquis)®, a Potent orally active factor Xa Inhibitor
Anastasios Polyzos, CSIRO, Melbourne, Australia
Flow Chemistry an Enabling Technology for Chemical Synthesis
Prasad Rao, Osmania Unversity, India
Synthesis of Bioactive 4-methyl-6-[(1-alkyl-1H-1,2,3,-triazol-4-yl)methoxy]-2H-chromen-2-one by Using Click Reaction
Jack Ryan, CSIRO, Australia
Dipolar Cycloaddition Reactions of a Non-stabilised Azomethine Ylide with Carboxyl Dipolarophiles: Reaction Cascades and Novel Heterocycles
Paul Stevenson, Queens University, UK
Chemoenzymatic Synthesis of (-)-Epibatidine
Tarmo Tamm, Molcode, Estonia
Predictive in silico analysis in practice - routine assessment and regulatory
Kourosch Tehrani, University of Antwerp, Belgium
Syntheses of 1,4-naphthoquinone annulated azaheterocyclic compounds
Rajeswar Rao Vedula, National Institute of Technology, India
Synthesis of Heterocyclic Compounds by Multi-component Reactions
Akhilesh K. Verma, University of Delhi, India
New Strategies for the Synthesis of Fused Heterocycles, Natural Products-like and π-Conjugated Scaffolds by the Electrophilic Cyclization of Alkynes
Stephen Waters, The University of Vermont, US
Strategies for the Synthesis of Nitrogen Heterocycles and Alkaloid Natural Products
Paul Watts, University of Hull, UK
Organic synthesis in micro and continuous flow reactors
Poster Session
The poster session will be combined with a complimentary wine bar and buffet on the evening of Monday, March 5th and will continue with wine reception on the evening of March 6th. It is expected that some fifty posters will be presented.
FloHet-2012 Sponsors, Exhibitors, and Advertisers
We are most grateful for the generous support of FloHet-12 by our sponsors, exhibitors, and advertisers - ADESIS, CEM, Elsevier, HEL, IUPAC, Mettler Toledo, MolCode, Oakwood Products, Royal Society of Chemistry, SigmaAldrich, Strem, Synthonix, Taylor & Francis, The Alachua County Visitors and Convention Bureau, and Thieme Chemistry.
ADESIS, INC. supports the pharmaceutical, biomaterials, and catalysts industries with excellent chemistry services. Outsourcing allows chemists to focus on the design and assembly of new targets for pharmacological evaluation and streamlines early stage drug discovery. We produce a Catalog of Heterocyclic Intermediates, deliver high quality products, succeed with difficult chemistry, and always adds value to our client-based programs. See www.adesisinc.com.
METTLER TOLEDO offers real time reaction monitoring for faster reaction optimization and improved continuous process production for flow reactor technology. FlowIR™ is a compact FTIR spectrometer designed specifically for in situ, real-time monitoring of a continuous flow stream. Its compact means it can be connected inline at any point of the flow reaction setup. www.mt.com/flowchemistry
MOLCODE offers theoretical modeling and predictive testing of chemicals and processes, reducing the need for laboratory tests or pointing out potential adverse effects. Combined in silico and laboratory approach allows to process new ideas more efficiently and to develop new chemicals/drug candidates without committing substantial resources at an early stage.
OAKWOOD PRODUCTS, a manufacturer and distributor, supplies research chemicals to the pharmaceutical, agrochemical and materials research communities. Oakwood's product listing contains over 40,000 items, including many unique building blocks, reactive intermediates and heterocyclic compounds. Visit us at our new e-commerce enabled website: www.oakwoodchemical.com.
Strem Chemicals manufactures and markets a wide range of metals, inorganics, organometallics and nanomaterials for research and development including metal catalysts and ligands for organic synthesis, MOCVD/ALD precursors, metal-based nanoparticles, powders, magnetic fluids, and carbon-based nanoproducts for use in the pharmaceutical, microelectronics, chemical and petrochemical industries. Custom synthesis work is provided on a contract basis. cGMP manufacturing is also available.
SYNTHONIX specializes in the medicinal chemistry driven design of novel 3-dimensional building blocks. These compounds are designed to allow our customers access to unexplored chemical space. Our team of scientists includes Ph.D., Masters, and Bachelor level chemists. Synthonix is focused on delivering high quality products and exceptional satisfaction to all of our customers. We have a 10,000 square foot research and manufacturing facility located in Wake Forest, North Carolina.
THIEME CHEMISTRY publishes highly evaluated information about synthetic and general chemistry for professional chemists and advanced students since 1909.
Our portfolio includes the well known journals SYNFACTS, SYNLETT and SYNTHESIS, the renowned synthetic methodology reference work Science of Synthesis, RÖMPP, the largest chemical encyclopedia published in German, and monographs. www.thieme-chemistry.com
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