Oxidative allene amination for the synthesis of nitrogen-containing heterocycles

,

Synthesis of the core of jogyamycin 5.
Concluding Remarks

Key features of chiral allenes enabling stereoselective syntheses of amine triads
Chiral allenes contain unique structural features poised to enable the tunable introduction of three new heteroatoms at each site of unsaturation (Scheme 1).6][47][48][49][50] Allenes are more stereochemically flexible than their alkene counterparts, as a single allene can be selectively transformed into multiple stereoisomeric products.Finally, allenes offer the potential for the controlled introduction of an array of heteroatoms into the triad in a versatile manner.Scheme 1. Goals for transition metal-catalyzed oxidative allene amination.
The key to harnessing the power of the allene synthon to deliver amine triads hinges on exploiting a chemo-, regio-, and stereoselective aziridination that generates reactive, strained methyleneaziridine (MA) intermediates (Scheme 1).Depending on the regioselectivity, two MA intermediates are possible, both of which display remarkable versatility in subsequent transformations to deliver acyclic and heterocyclic amines.In this review, we discuss several strategies to transform allenes to amine triad building blocks through the intermediacy of MAs, as well as applications of this chemistry to the preparation of bioactive molecules and the exploration of novel amine chemical space.

Exocyclic bicyclic methyleneaziridines (MA) from sulfamate nitrene precursors
The first challenge in developing oxidative allene amination methodologies was to identify robust methods to achieve chemo-, regio-and stereoselective allene aziridination.5][56] While the labile 2 could be observed by NMR, it was readily opened in the presence of water or silica gel.Therefore, the aziridination was followed by immediate ring-opening to afford the enesulfamate 3 in good yield and excellent stereoselectivity in favor of the E isomer. 54heme 2. Rh(II)-catalyzed aziridination of homoallenic sulfamates to bicyclic methyleneaziridines.

Endocyclic methyleneaziridines (MA) from sulfamate nitrene precursors
Reaction at the distal C2-C3 double bond of 4a-c (Scheme 3) to generate endocyclic methyleneaziridines was achieved by installing a silyl group at C1 of the allene. 57The electronic effect exerted by the trialkylsilyl group stabilizes the developing positive charge on the β carbon in the transition state through hyperconjugative interaction with the C-Si bond that is coplanar with the distal π orbitals, leading to 5c.Monoalkyl substitution on C3 was well-tolerated in this chemistry, as was alkyl substitution in the tether between the allene and the sulfamate; however, 1,1',3,3'-tetrasubstituted allenes gave only elimination products.In contrast to the exocyclic MAs described in Section 2.1, endocyclic MAs were stable to column chromatography and could be readily isolated.Scheme 3. Electronic control over the regioselectivity of allene aziridination at the C2-C3 bond.

Exocyclic methyleneaziridines (MA) from carbamate nitrene precursors
To expand the versatility of oxidative allene amination, homoallenic carbamates of the form 6 were explored in intramolecular allene aziridination (Scheme 4).1][62] Approximately equimolar amounts of AgOTf and a phen ligand transformed allenes 6a-c of diverse substitution patterns selectively into MAs 7a-c with moderate-to-good E:Z ratios; the two isomers were easily separated by column chromatography.The carbamoyl-derived MAs were more robust than the analogous sulfamoyl-derived MAs and survived column chromatography with no competing ring-opening.Scheme 4. Ag(I)-catalyzed aziridination of homoallenic carbamates.

Strategies for the Synthesis of Heterocycles from Oxidative Allene Amination
With methods in hand for chemo-, regio-, and stereo-selective syntheses of bicyclic MAs from allenes, chemistry to exploit their unusual features was explored.Scheme 5 presents a summary of the complex amine scaffolds accessible from 9 through the intermediacy of 10 and 11.Approaches are divided into four main strategies; Section 3.1 addresses the ring-opening of sulfamoyl-derived aziridines 10 with an array of nucleophiles ultimately to furnish triads 12 with stereochemical flexibility at C1-C3.Section 3.2 describes reactions of carbamoyl-derived MAs 10 to furnish aminodiols and diaminoalcohols of the form 13-14. Ring expansion strategies in Section 3.3 enable access to densely substituted azetidines 15 and 17, heterocycles that are challenging to prepare with other synthetic methods.Finally, bicyclic MAs provide a convenient way to access 2-amidoallyl cation intermediates 18, which are under-explored compared to their 2-oxallyl cations; this chemistry is discussed in Section 3.4.Scheme 5. Summary of oxidative allene amination methods.

Tandem allene aziridination/nucleophilic ring-opening
Two major advantages of utilizing MAs as reactive intermediates are their strain (ca.42 kcal/mol) and the ability to exquisitely control the regioselectivity of nucleophilic ring-opening.Sulfamoyl-containing MAs are not isolable, but their high reactivity enables a convenient one-pot process to convert allenes to triads bearing contiguous, stereodefined C(sp 3 )-X or C(sp 3 )-C bonds. 54Selected scope for the four-step, one-pot process is shown in Scheme 6 and entails: 1) aziridination of 20, 2) in situ ring-opening of 21, 3) electrophilic substitution of the resulting enesulfamate 22 to furnish 23, and 4) a final imine reduction to furnish 24.The ring strain and leaving group ability of the sulfamoyl group in 21 enabled diverse nucleophiles, including alcohols, carboxylic acids, amines, thiols, halides and water, to open the aziridine at rt.The resulting enesulfamates 22 reacted with a variety of electrophiles to introduce halogen, oxygen, sulfur, and nitrogen groups at C3 of the original allene.Imine 23 could be reduced with hydride, cyanide, or Grignard nucleophiles to give triad 24.The 1,2-syn:2,3-syn diastereomer was typically the major product, due to the conformations adopted by 22 and 23 to minimize A 1,3strain.The heteroatoms flanking the C2 amine could be tuned to give a diverse array of triads in good dr, including 25-29.Importantly, efficient axial-to-point chirality transfer from the allene precursor to the triad was noted for 30.

Scheme 7. Introduction of fluorine into all-syn amine stereotriads.
In addition to flexibility in the identity of the heteroatoms that can be introduced into amine triads, oxidative allene amination offers the potential for stereochemical versatility.For example, stereodivergent syntheses of O/N/O triads from single allene precursors has been achieved. 73The general strategy is shown in Scheme 8A, where a single enantioenriched allene 45 can be converted to any one of the four possible diastereo-and enantioenriched amine triads 49, 52, 53, and 56.
The stereodivergent oxidative allene amination begins with a one-pot transformation of 45 to 47, where a bulky OTBS group at C1 ensures good dr in the subsequent addition of 47 to dimethyldioxirane (DMDO) to give 1,3-anti-48, presumably via a concerted addition displaying an early transition state.The oxidation event can be telescoped with the reduction using Zn(BH4)2 to yield the 1,2-syn:2,3-anti triad 49.Yields over the two steps are in the range of 80-84% (Scheme 8B, left) with moderate-to-good dr.Access to the remaining diastereomers requires isomerization of (E)-47 to (Z)-50, which is achieved in near-stoichiometric yield using a one-pot addition/elimination sequence.Conversion of 50 to the 1,2-anti:2,3-anti triad 53 proceeds in a similar fashion to that described for reaction of 47. Selected scope is illustrated in Scheme 8B, right-hand table, furnishing 62-90% yields of the triads over the two steps with good dr.The reader is referred to the original reference for the scope of the remaining two triads 52 and 56. 73heme 8. Stereochemical diversity in oxidative allene amination.

Treatment of MA with electrophilic reagents
An alternative mode of reactivity of bicyclic MA intermediates involves functionalizing the exocyclic alkene prior to aziridine ring-opening.In this context, a carbamate nitrene precursor was necessary to ensure that the MA 57 was stable and isolable.The bicyclic ring renders electrophilic transformations of the alkene highly diastereoselective.For example, treatment of MAs of the form 57 (Scheme 9) with N-aminophthalimide (PhthNNH2) in the presence of PhIO resulted in complete facial selectivity to give tricyclic 1,4-diazaspiro-[2.2]pentanes58 (DASPs) in >19:1 dr.Monoalkyl substitution 58 at C3 of the MA furnished 59-62 in good yields.The substitution pattern of the original allene, and hence the MA, could be varied to furnish DASPs 62-63 in good-to-moderate yields.One important feature of this 'intra/intermolecular' aziridination strategy is that the two rings of the DASP are electronically differentiated; the bicyclic aziridine contains an electron-withdrawing group, while the spiro ring bears an electron-donating group.Methods to selectively open either of these rings have been reported by our group; however, the difficulty of cleaving the N-N bond of the protecting group limits the utility of DASPs in this context. 58heme 9. Intermolecular aziridination of methyleneaziridines to 1,4-diazaspiro [2.2]pentanes.
Aminohydroxylation of carbamoyl-derived MA 74 furnished 1,3-diamino-2-ols 76 in good dr, provided a gem-dimethyl group was present in the precursor (Scheme 11). 75The initial oxidation event gave direct access to the 1,3-diaminoketone products 77-82, with the exocyclic nitrogen protected with an easily cleaved sulfonyl or Boc group.Selective reduction was achieved using NaBH4 in either CH2Cl2 or a 1:1 mixture of CHCl3:H2O to give 77a-82a.The process was general for a variety of alkyl-and aryl-substituted MAs derived from 1,3disubstituted allenes, although the identity of the chloramine was crucial to obtain good yields.For example, sulfonamides (Conditions A-B) worked best for alkyl-substituted allenes, while BocNNaCl was a better nitrogen source when the allene was aryl-substituted.In contrast to the dihydroxylation of MAs, 1,3,3'-trisubstituted MAs were not tolerated and the gem-dimethyl group was critical for good dr in the reduction.Scheme 10.Stereocontrolled dihydroxylation of MA to furnish 1-amino-2,3-diols.Scheme 11.Aminohydroxylation/reduction of MA to furnish 1,3-diamino-2-ols.

Ring-expansion strategies
Azetidines are four-membered saturated nitrogen heterocycles that are of interest for the rigidification of alkylsubstituted amines and for their potential as pharmaceutical candidates.7][78][79][80][81][82][83] Ring-expansion reactions of both sulfamoyl-and carbamoyl-derived MAs present a unique opportunity to provide stereocontrolled access to these heterocycles from allene precursors.
Endocyclic MAs are generated via aziridination of the distal allene double bond of a silylated allene 83 (Schemes 12 and 3, vide supra). 57Following formation and purification of the column-stable MA 84, oxidation of the double bond with mCPBA delivered the fused azetidin-3-one 86 in good yield and excellent dr.Scheme 12. Selected substrate scope of the azetidin-3-one formation from endocyclic MA.Formation of 86 was proposed to occur through rearrangement of a transient 1,4-oxaza-[2.2]spiropentane85, although this intermediate was not observed spectroscopically.In terms of the substrate scope, 1,1',3trisubstituted allenes were well-tolerated to furnish heterocycles 87-92.The size of the silyl group at R 2 (TBS vs. TES vs. TMS) did not affect the regioselectivity or the subsequent transformation of the endocyclic MA to the azetidinone, but could be engaged to control subsequent functionalizations of the heterocycle (Scheme 13).When diastereomeric mixtures of allenes were employed, two diastereomeric azetidinones were formed (not shown); these could be readily separated by column chromatography.In all cases, axial-to-point chirality transfer occurred with excellent fidelity to deliver enantioenriched products.
Further manipulations of azetidin-3-ones could be carried out by opening the sulfamate ring of the TBSsubstituted 93 with nucleophiles to give 95-97 (Scheme 13A), where the bulky TBS group blocks the expected reaction at the carbonyl group.In contrast, the use of a TMS group on allenes of the form 83 leads to desilylation; treatment of the representative azetidin-3-one 98 gave reaction at the carbonyl group to deliver 99-102 (Scheme 13B). 57cheme 13.Further manipulations of azetidin-3-ones controlled by the identity of the silyl group.
62]84 Addition of a Rh2(OAc)4 catalyst and a donor/acceptor carbene precursor 105 results in a stereoselective, one-carbon ring expansion to yield highly substituted methyleneazetidines of the form 106. Phenyl diazoacetate, as well as electron-rich and electron-poor aryl diazoacetates, were successful in the reaction to furnish azetidines 107-111 in 78-92% yield and >19:1 dr. 84rtho substitution on the aryl ring of the carbene was tolerated, as were heterocycles represented by 112.The aryl group of the donor/acceptor carbene precursor could be replaced with an alkyl or vinyl group, as in 113-114; alternatively, a styrenyl-based carbene precursor cleanly gave azetidine 115.
Alkyl-substituted E-MA isomers (>10:1 E:Z) were successful in the reaction, delivering 116-117 in good yields and excellent dr.While 1,3,3'-trisubstituted allene precursors gave bicyclic MAs that reacted slowly with bulky carbene partners, employing a less-hindered styrenyl diazo precursor gave fully substituted azetidine 118 in 94% yield.A highlight of the method was the conversion of a 4:1 mixture of E/Z isomers of a chiral MA to 119 in 3:1 dr and 89% yield.The diastereomers were easily separated to give the syn-Me/CO2Me isomer of 119 in 54% yield and 15:1 dr.Scheme 14. Rh-catalyzed one-carbon ring expansions of carbamoyl-derived methyleneaziridines.

Scheme 15. Further transformations of bicyclic methyleneazetidines.
Methyleneazetidine 120 was further functionalized via hydrogenation to give azetidine 121 in high dr (Scheme 15).Baran's iron-catalyzed C-C coupling successfully delivered 122 in good dr to forge a second quaternary stereocenter on the azetidine. 85Attempts to oxidatively cleave the alkene to give the β-lactam were unsuccessful, due to the tendency of the 120 to undergo ring-opening to furnish the interesting macrocycles 123-124 in good yield and dr.
Mechanistic studies of this unusual Rh-catalyzed aziridine ring expansion showed that the chirality was transferred from the enantioenriched MA (S)-125 to the azetidine (S,S)-129 with excellent fidelity (Scheme 16). 84xperimental and computational studies support the formation of an initial aziridinium ylide 127 via attack of the nitrogen on the Rh-bound carbene.Loss of Rh to 128, followed by concerted [2,3]-Stevens rearrangement furnishes the azetidine product (S,S)-129. 84,86heme 16.Mechanistic insight into Rh-catalyzed [3+1] ring expansions of Mas.

Formation and trapping of 2-amidoallyl cation intermediates
8][89][90][91] Allene aziridination of 130 to 131 (Scheme 17) offers a stereodivergent approach to the synthesis of cycloheptenes of the form 134. The general strategy involves the use of different reaction conditions to control the geometry of the 2-amidoallyl cation 132. 92In this manner, the stereochemistry of the subsequent [4+3] cycloaddition with furan to furnish 133 could be altered in a tunable manner. 93Likewise, reagent-controlled reduction in the transformation of 133 to 134 provides an opportunity to vary the relative stereochemistry between the amine at C2 and the stereochemistry at C1 and C3 of the original allene precursor.In this manner, stereodivergent syntheses of four different stereoisomers of 134 from a single allene might be accomplished.

Scheme 17. General strategy for stereodivergent transformations of allenes to carbocycles.
Stereodivergent [4+3] reactions were initiated by treating allene 135 with catalytic Rh2TPA4 to generate 136 in situ.Addition of a 1:1 mixture of furan/THF furnished the 1,3-syn heterocycle 139 through the intermediacy of 137, whereas a 1:1 furan/MeNO2 mixture delivered the 1,3-anti heterocycle 142 via 138. 93Further stereodivergence was accomplished in reagent-controlled reduction of the imines of 139 and 142.Small hydrides, such as NaBH3CN, favored approach of the nucleophile from the top face of 139 to furnish 141, while reaction of 142 provided 144.A bulky LiBHEt3 reductant with 139 favored 140, provided R 2 was H. Unfortunately, the use of LiBHEt3 with 142 did not deliver 143 in good dr, and AlH3Me2NEt was required to yield the final diastereomer 143, albeit with limited scope.The reaction sequence could be accomplished in one pot, with moderate yields over the three steps (Scheme 18, bottom for one example) and moderate-to-excellent dr.As expected, formation of the achiral 2-amidoallyl cation precluded effective transfer of axial-to-point chirality; however, an external asymmetric center was able to control the diastereoselectivity of the [4+3] reaction to yield product in 97% ee (not shown). 93heme 18. Stereodivergent, [4+3] cycloadditions of furan with 2-amidoallyl cations from allenes.
Despite the moderate yields, this one-pot sequence significantly increases the structural complexity of a simple allene to give densely functionalized carbocycles.The products can be manipulated in a number of ways (Scheme 19), including ring-opening to yield 150-151, ring contraction to deliver the pyrrolidine 152, opening of the oxygen bridge to furnish 153-154, diastereoselective dihydroxylation to provide a fully substituted cycloheptane 155, and addition of carbon nucleophiles to 149 to give 156.Scheme 19.Synthetic utility of cycloheptene products.

Applications to the Synthesis of Complex Molecules
In addition to developing the utility of allenes for the synthesis of amine triads, we wanted to demonstrate how these methods might be utilized to synthesize complex molecules.Targets include novel aminosugars, unnatural and unique amino acids and aminocyclitol scaffolds.

Synthesis of aminosugars
5][96][97][98] While aminosugars, such as neuraminic acid and glucosamine, are commonly found in nature, there continues to be a need for versatile strategies to prepare 'designer' aminosugars with specific properties for incorporation into glycoconjugates.The ability to flexibly install three contiguous heteroatom-bearing stereocenters at each unsaturated carbon of an allene, coupled with control over relative stereochemistry and effective axial-to-point chirality transfer, has the potential to deliver useful building blocks for aminosugar libraries.
An example of the strategy employed for aminosugar synthesis from allenes is outlined in Scheme 20. 99 Enantioenriched allene 157 was easily prepared from D-mannitol; a one-pot aziridination to 158, followed by water ring-opening and alcohol protection furnishes the enesulfamate 159.Treatment of 159 with DMDO and a reductant yielded the 2-amino-1,3-diol motif 161 as a 4.1:1 mixture of easily separable diastereomers.A onepot removal of the sulfamoyl group and cleavage of the resulting olefin via ozonolysis gave a protected derivative of 3-deoxy-3-amino-D-allose 163.
While stereochemical flexibility in this chemistry (Scheme 8) was not thoroughly explored, Amadori-type rearrangement of α-hydroxyimine 160 to the α-aminoketone 164 (Scheme 20, bottom), followed by reduction with LiBEt3H, gave 165 as the major stereoisomer, which maps onto 3-amino-3-deoxy-D-gulose. 99We envisage this strategy could also be engaged to introduce a number of other heteroatoms into amine triads to furnish novel aminosugars.Scheme 20.Synthesis of aminosugar building blocks via oxidative allene aziridination.
4.2 Synthesis of unusual and unnatural amino acids, and fluorinated pyrrolidines 4.2.1.Total synthesis of (±)-detoxinine, its methyl ester, and stereoisomers.1][102] The stereochemical flexibility of oxidative allene amination, as described in Scheme 8, enables a single homoallenic sulfamate 166 to be transformed to all four possible diastereomers of the methyl ester of detoxinine.A representative O/N/O triad 167 (Scheme 21) was prepared from 166 and transformed into methyldetoxinine.Protection of the free secondary alcohol of the all-syn stereotriad 167 gave 168 in 85% yield.A Boc group was installed on the amine, followed by a NaI-mediated ring contraction to give intermediate 169, which was immediately subjected to Tamao-Fleming oxidation to furnish 170 in 67% yield from 168.A two-step oxidation sequence, followed by an acidic workup, delivered the product (±)-detoxinine methyl ester 171. 100 The same sequence of reactions could be applied to the three remaining diastereomers of 166 (172, 174 and 176, Scheme 21, bottom) to give diastereomeric analogues of detoxinine, 173, 175 and 177.Scheme 21.Total synthesis of (±)-detoxinine methyl ester and stereoisomers.

Fluorinated pyrrolidines and unnatural amino acids.
8][109] Oxidative allene amination of 178 gave the triad 179 in moderate dr (Scheme 7, vide supra).The nitrogen was protected with a Boc group and the crude material subjected to a NaImediated ring contraction and purification to deliver the pyrrolidine product 180 in good yield and a dr >19:1.Scheme 22. Synthesis of a fluorinated pyrrolidine scaffold through ring contraction.
][117][118] The fluorinated amine triads 182 and 184 obtained from the allene precursor 181 through the chemistry described in Scheme 7 are readily transformed in a few steps to α-, β-and γ-amino acids (Scheme 23).Ozonolysis of 182, followed by Pinnick oxidation, yields the α-amino acid 183 in good yield.Triad 184 served as the substrate for the synthesis of β-and γ-amino acids.For example, the preparation of the protected β-amino acid 186 proceeded through an initial one-pot, three-step elimination of the sulfamate group of 184 to yield 185.
Ozonolysis, Pinnick oxidation and esterification furnished 186.The protected γ-amino acid 188 was obtained through the same intermediate 185 via a sequence involving hydroboration and RuCl3-catalyzed oxidation of the alcohol to the carboxylic acid.The ability to transfer axial-to-point chirality from 181 to the amino acid products 183, 186, and 188 enables access to either enantiomer of these scaffolds.

Scheme 23.
Transformations of fluorinated amine triads to unnatural amino acids.

Synthesis of the core of jogyamycin
The aminocyclopentitol core of jogyamycin.The natural product jogyamycin was isolated in 2012 from a culture broth of Streptomyces sp.a-WM-JG-16.2 (Figure 2). 152The molecule is a complex aminocyclopentitol, where each of the carbons in the core cyclopentane ring is functionalized with a stereodefined hydroxyl or amino group.1][122][123][124][125][126] Jogyamycin exhibits potent antiprotozoal activity against organisms that cause malaria and African sleeping sickness, while pactamycin and its analogs have been reported to display anticancer, antiviral and antimicrobial activities, in addition to antiprotozoal activities. 1198][129][130] Despite the similar binding sites for aminocyclitols in bacterial and mammalian cells, subtle structural changes in the aminocyclitol core can alter the activity of these natural products for reasons that are not yet well-understood. 121,1222][133][134][135][136][137][138][139][140][141][142] However, these efforts have either been unsuccessful or do not allow for deep-seated changes to the core of the molecule, rendering any future explorations of structure-activity relationships challenging.In order to investigate the impact of targeted changes to the core of jogyamycin on biological activity, we have applied oxidative allene amination to the synthesis of analogues of this natural product (Scheme 24). 143A three-step, one-pot conversion of allene 189 to 191 was followed by another three-step, one-pot sequence to transform the enesulfamate 191 to the triad 192 in a dr of 11.5:1, which increased to >20:1 after purification.N-Boc protection of 192 furnished 193; ring-opening of the sulfamate with a thiophenol nucleophile to 194 was followed by a one-pot, three-step sequence to install the alkene of 195 in a yield of 68% over the three steps.Chelation-controlled addition of isopropenylMgBr to 195 gave the amine triad 196 in >20:1 dr.Scheme 24.Synthesis of the core of jogyamycin via oxidative allene amination.
Removal of the TBS protecting group from the secondary alcohol of 196 was required for successful ringclosing metathesis using Grubbs II catalyst to deliver cyclopentene 197 in 91% yield and >20:1 dr.In addition to accessing the core of jogyamycin, this approach offers flexibility in terms of the introduction of other heteroatoms into the cyclopentane core.

Concluding Remarks
Transition metal-catalyzed allene amination methods complement those of conventional alkene oxidation for the synthesis of complex amine-containing stereotriads.A chemo-, regio-, and stereo-selective allene aziridination reaction furnishes key bicyclic methyleneaziridines (MA) that can be manipulated in diverse ways.Ring-opening of the sp 3 aziridine carbon of the MA initiates a one-pot sequence to deliver C-X 1 /C-N/C-X 2 triads, where the identities of the two flanking heteroatoms can be readily varied.This strategy was applied to the syntheses of aminosugars, detoxinine and its stereoisomers, fluorinated pyrrolidines, unnatural α-, β-and γaminoacids, and the core of a bioactive aminocyclopentitol, jogyamycin.The axial chirality of the allene offers the ability to achieve stereodivergence in the resulting triad products, as also enables axial-to-point chirality transfer in many cases.
In contrast to the direct nucleophilic ring-opening of MAs, diastereoselective dihydroxylations and aminohydroxylations on the exocyclic double bond of MAs furnished aminodiols and diaminoalcohols.Ring expansion of MAs to heterocycles, including azetidin-3-ones, methyleneazetidines, and unique sulfamoylcontaining cyclooctynes were reported.Finally, treatment of MAs with heat or Lewis acid generates 2-amidoallyl cations that could be trapped with furan in a stereodivergent manner to deliver aminated cycloheptene scaffolds were described.
Remaining synthetic challenges include the development of selective, intermolecular allene aminations, transition metal-catalyzed strategies to convert racemic allenes to enantioenriched triads, and converting each unsaturated carbon of the allene to a new sp 3 C-C bond. in 2009.Her research interests include catalyst-controlled C-H oxidations, methods for allene functionalizations and the total synthesis of complex bioactive molecules.