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ARKIVOC Volume 2004
Part (v): Commemorative Issue in Honor of Prof. Vincenzo Tortorella on the occasion of his receiving Fuori Ruolo status
Facilitator: Girolamo Cirrincione
Scientific Editor: Viktor V. Zhdankin

Graphical Abstracts
1. A Tribute to Prof. Vincenzo Tortorella (VT-488LT)
Girolamo Cirrincione
DOI: https://doi.org/10.3998/ark.5550190.0005.501
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pp. 1 - 4
accepted Sep 29 2003; published Oct 10 2003;
2. H-NMR determination of the enantiomeric excess of the antiarrhytmic drug Mexiletine by using mandelic acid analogues as chiral solvating agents (VT-850LP)
Giuseppe Carbonara, Alessia Carocci, Giuseppe Fracchiolla, Carlo Franchini, Giovanni Lentini, Fulvio Loiodice and Paolo Tortorella
DOI: https://doi.org/10.3998/ark.5550190.0005.502
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pp. 5 - 25
received Jul 29 2003; accepted Oct 6 2003; published Oct 17 2003;
3. Synthetic approaches to difluoroindolecarboxylic acid ethyl esters (VT-856LP)
Romano Silvestri, Marino Artico, Giuseppe La Regina and Gabriella De Martino
DOI: https://doi.org/10.3998/ark.5550190.0005.503
Full Text: PDF (118K)
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pp. 26 - 31
received Aug 1 2003; accepted Dec 12 2003; published Dec 27 2003;
4. Synthesis and biochemical evaluation of (R)-5-acyloxymethyl- and (S)-5-acylaminomethyl-3-(1H-pyrrol-1-yl)-2-oxazolidinones as new anti-monoamine oxidase (anti-MAO) agents (VT-941LP)
Antonello Mai, Marino Artico, Sergio Valente, Ilaria Cerbara, Olivia Befani, Paola Turini Laura Dalla Vedova and Enzo Agostinelli
DOI: https://doi.org/10.3998/ark.5550190.0005.504
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pp. 32 - 43
received Oct 6 2003; accepted Nov 26 2003; published Jan 9 2004;
5. Synthesis and pharmacological evaluation of 7-substituted 1-ethyl-3,4,10-trimethyl-1,10-dihydro-11H-pyrazolo[3,4-c][1,6]benzodiazocin-11-one. A new ring system (VT-989LP)
Onofrio Migliara, Salvatore Plescia, Patrizia Diana, Vita Di Stefano, Lorenzo Camarda and Roberta Dall’Olio
DOI: https://doi.org/10.3998/ark.5550190.0005.505
Full Text: PDF (72K)
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pp. 44 - 53
received Nov 24 2003; accepted Jan 15 2004; published Jan 15 2004;
6. Glyceroglycolipids from Euphorbia nicaeensis All. with antiinflamatory activity (VT-976LP)
Francesca Cateni, Gioacchino Falsone, Jelena Zilic, Paolo Bonivento, Marina Zacchigna, Dušan Žigon, Silvio Sosa and Gianmario Altinier
DOI: https://doi.org/10.3998/ark.5550190.0005.506
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pp. 54 - 65
received Nov 6 2003; accepted Jan 15 2004; published Jan 21 2004;
7. A new synthesis of triazolo[4,5-g]quinolines and unexpected ring reduced products by treatment with hydrazine hydrate (VT-972LP)
Antonio Carta and Giuseppe Paglietti
DOI: https://doi.org/10.3998/ark.5550190.0005.507
Full Text: PDF (128K)
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pp. 66 - 75
received Nov 5 2003; accepted Feb 4 2004; published Feb 11 2004;
8. 2-[(E)-3-(6-chloroimidazo[2,1-b]thiazol-5-yl)prop-2-enyl]-5,6-dimethoxy-3-methyl-1,4-benzoquinone: a new inhibitor of NADH dehydrogenase with antitumor activity (VT-925LP)
Aldo Andreani, Massimiliano Granaiola, Alberto Leoni, Alessandra Locatelli, Rita Morigi, Mirella Rambaldi, Giorgio Lenaz, Romana Fato, Christian Bergamini
DOI: https://doi.org/10.3998/ark.5550190.0005.508
Full Text: PDF (136K)
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pp. 76 - 84
received Sep 17 2003; accepted Feb 4 2004; published Feb 12 2004;
9. Synthesis of new pyrido[4,3- g and 3,4- g]quinoline-9,10-dione and dihydrothieno[2,3- g and 3,2-g]quinoline-4,9-dione derivatives and preliminary evaluation of cytotoxic activity (VT-960LP)
Isabel Gomez-Monterrey, Pietro Campiglia, Teresa Lama, Paolo La Colla, Maria V. Diurno, Paolo Grieco, Ettore Novellino
DOI: https://doi.org/10.3998/ark.5550190.0005.509
Full Text: PDF (193K)
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pp. 85 - 96
received Oct 27 2003; accepted Feb 10 2004; published Feb 14 2004;
10. Synthesis of pyrrol-[1,2-a]indole-1,8(5H)-diones as new synthones for developing novel tryciclic compounds of pharmaceutical interest (VT-1012LP)
Mario Sechi, Alessio Mura, Luciano Sannia, Maria Orecchioni and Giuseppe Paglietti
DOI: https://doi.org/10.3998/ark.5550190.0005.510
Full Text: PDF (174K)
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pp. 97 - 106
received Dec 17 2003; accepted Feb 10 2004; published Feb 14 2004;
11. Molecular modeling of β-cyclodextrin inclusion complexes with pharmaceutical compounds (VT-988LP)
Stefano Alcaro, Danilo Battaglia and Francesco Ortuso
DOI: https://doi.org/10.3998/ark.5550190.0005.511
Full Text: PDF (231K)
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pp. 107 - 117
received Nov 24 2003; accepted Feb 17 2004; published Feb 21 2004;
12. Synthesis and biological evaluation of 3-alkyloxazolidin-2-ones as reversible MAO inhibitors (VT-1015LP)
Claudia Lamanna, Maria Stefania Sinicropi, Paola Pietrangeli, Filomena Corbo, Carlo Franchini, Bruno Mondovì and Antonio Scilimati
DOI: https://doi.org/10.3998/ark.5550190.0005.512
Full Text: PDF (146K)
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pp. 118 - 130
received Dec 18 2003; accepted Feb 17 2004; published Feb 21 2004;
13. Methyl derivatives of tetracyclic psoralen analogues: antiproliferative activity and interaction with DNA (VT-1027LP)
Lisa Dalla Via, Eugenio Uriarte, Lourdes Santana, Sebastiano Marciani Magno and Ornella Gia
DOI: https://doi.org/10.3998/ark.5550190.0005.513
Full Text: PDF (241K)
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pp. 131 - 146
received Dec 22 2003; accepted Feb 20 2004; published Mar 4 2004;
14. Microwave-induced synthesis of benzimidazole and thiazolidinone derivatives as HIV-1 RT inhibitors (VT-1030LP)
Angela Rao, Alba Chimirri, Stefania Ferro, Anna Maria Monforte, Pietro Monforte and Maria Zappalà
DOI: https://doi.org/10.3998/ark.5550190.0005.514
Full Text: PDF (60K)
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pp. 147 - 155
received Dec 23 2003; accepted Mar 2 2004; published Mar 5 2004;
15. 1-Phenyl-3-azabicyclo[3.1.0]hexane derivatives as new ligands for sigma receptors (VT-1017LP)
Agostino Marrazzo, Andrea Pappalardo, Orazio Prezzavento, Franco Vittorio
DOI: https://doi.org/10.3998/ark.5550190.0005.515
Full Text: PDF (140K)
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pp. 156 - 169
received Dec 18 2003; accepted Mar 2 2004; published Mar 5 2004;
16. Synthesis and anticonvulsant properties of 1,2,3,4-tetrahydroisoquinolin-1-ones (VT-1067LP)
Rosaria Gitto, Maria L. Barreca, Eleonora Francica, Roberta Caruso, Laura De Luca, Emilio Russo, Giovambattista De Sarro, Alba Chimirri
DOI: https://doi.org/10.3998/ark.5550190.0005.516
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pp. 170 - 180
received Dec 22 2003; accepted Mar 4 2004; published Mar 10 2004;
17. A general, versatile synthesis of 2H-pyrrolo[3,4-c]quinolines via tosylmethylisocyanide reaction (VT-1041LP)
Roberto Di Santo, Roberta Costi, Michela Forte and Carlo Galeffi
DOI: https://doi.org/10.3998/ark.5550190.0005.517
Full Text: PDF (154K)
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pp. 181 - 195
received Jan 14 2004; accepted Mar 2 2004; published Mar 10 2004;
18. Synthesis of 5-substituted 7,9-dihydro-8H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-8-ones as anticonvulsant agents (VT-1018LP)
Maria Zappalà, Nicola Micale, Silvana Grasso, Frank S. Menniti, Giovambattista De Sarro and Carlo De Micheli
DOI: https://doi.org/10.3998/ark.5550190.0005.518
Full Text: PDF (120K)
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pp. 196 - 203
received Dec 19 2003; accepted Mar 5 2004; published Mar 10 2004;
19. Aminoacyl-analogues of mitoxantrone as novel DNA-damaging cytotoxic agents (VT-1019LP)
Giuseppe Zagotto, Claudia Sissi, Barbara Gatto and Manlio Palumbo
DOI: https://doi.org/10.3998/ark.5550190.0005.519
Full Text: PDF (334K)
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pp. 204 - 218
received Dec 20 2003; accepted Mar 17 2004; published Mar 19 2004;
20. DNA-binding and DNA-photocleavaging properties of 12a,14a-diazoniapentaphene (VT-1085LP)
Giampietro Viola, Heiko Ihmels, Hubert Kraußer, Daniela Vedaldi and Francesco Dall’Acqua
DOI: https://doi.org/10.3998/ark.5550190.0005.520
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pp. 219 - 230
received Jan 9 2004; accepted Mar 18 2004; published Mar 19 2004;
21. Antifungal and antimycobacterial activity of new N1-[1-aryl-2-(1H-Imidazol-1-yl and 1H-1,2,4-triazol-1-yl)-ethylidene]-pyridine-2-carboxamidrazone derivatives: A combined experimental and computational approach. (VT-1013LP)
Maria Grazia Mamolo,Daniele Zampieri, Valeria Falagiani, Luciano Vio, Maurizio Fermeglia,Marco Ferrone,Sabrina Pricl,Elena Banfi,and Giuditta Scialinoc
DOI: https://doi.org/10.3998/ark.5550190.0005.521
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pp. 231 - 250
received Dec 17 2003; accepted Mar 17 2004; published Mar 23 2004;
22. H-NMR and FT-IR study of the state of melatonin confined in membrane models: location and interactions of melatonin in water free lecithin and AOT reversed micelles (VT-1020LP)
David Bongiorno, Leopoldo Ceraulo, Mirella Ferrugia, Felice Filizzola, Cristina Giordano, Angela Ruggirello and Vincenzo Turco Liveri
DOI: https://doi.org/10.3998/ark.5550190.0005.522
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pp. 251 - 262
received Dec 20 2003; accepted Mar 24 2004; published Mar 26 2004;
23. Docking of indolo- and pyrrolo-pyrimidines to DNA. New DNA-interactive polycycles from amino-indoles/pyrroles and BMMA (VT-1079LP)
Antonino Lauria, Patrizia Diana, Paola Barraja, Alessandra Montalbano, Gaetano Dattolo, Girolamo Cirrincione and Anna Maria Almerico
DOI: https://doi.org/10.3998/ark.5550190.0005.523
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pp. 263 - 271
received Jan 5 2004; accepted Mar 29 2004; published Apr 1 2004;
24. Synthesis of potential dual binding site acetylcholinesterase inhibitors through an efficient solid phase approach based on the Mitsunobu reaction (VT-1078LP)
Francesco Leonetti, Anna Cappa, Cristina Maccallini and Angelo Carotti
DOI: https://doi.org/10.3998/ark.5550190.0005.524
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pp. 272 - 285
received Feb 12 2004; accepted Mar 29 2004; published Apr 1 2004;
25. Design, synthesis and preliminary pharmacological evaluation of rigid analogues of the nicotinic agonist 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP) (VT-1009LP)
Luca Guandalini, Elisabetta Martini, Fulvio Gualtieri, M. Novella Romanelli and Katia Varani
DOI: https://doi.org/10.3998/ark.5550190.0005.525
Full Text: PDF (207K)
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pp. 286 - 300
received Dec 17 2003; accepted Apr 4 2004; published Apr 5 2004;
26. Adenosine receptor agonists: synthesis and binding affinity of 2- (aryl)alkylthioadenosine derivatives (VT-1036LP)
R. Volpini, S. Costanzi, C. Lambertucci, F. R. Portino, S. Taffi, S. Vittori, K.-N. Klotz, G. Cristalli
DOI: https://doi.org/10.3998/ark.5550190.0005.526
Full Text: PDF (145K)
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pp. 301 - 311
received Dec 30 2003; accepted Apr 13 2004; published Apr 15 2004;
27. Synthesis of new 5-phenyl[1,2,4]triazole derivatives as ligands for the 5-HT1A serotonin receptor (VT-1039LP)
Loredana Salerno, Mariangela Siracusa, Francesco Guerrera, Giuseppe Romeo, Valeria Pittalà, Maria Modica, Tiziana Mennini and Filippo Russo
DOI: https://doi.org/10.3998/ark.5550190.0005.527
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pp. 312 - 324
received Dec 22 2003; accepted Apr 17 2004; published Apr 23 2004;
28. β-Aminomethylation of N-aryl- and N-azaheteroaryl-substituted methyl 2,5-dimethylpyrrole-3-carboxylates. Kinetic effect of the N-pyrrole substituent (VT-1014LP)
Mariangela Biava, Giulio Cesare Porretta, Giorgio Giorgi and Giancarlo Sleiter
DOI: https://doi.org/10.3998/ark.5550190.0005.528
Full Text: PDF (165K)
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pp. 325 - 333
received Dec 17 2003; accepted Apr 23 2004; published Apr 23 2004;
29. 9-Fluorenon-4-carboxamides: synthesis, conformational analysis, anti-HSV-2, and immunomodulatory evaluation. Note II (VT-1071LP)
Stefano Alcaro, Adriana Arena, Rosaria Di Bella, Simonetta Neri, Rosaria Ottanà, Francesco Ortuso, Bernadette Pavone and Maria Gabriella Vigorita
DOI: https://doi.org/10.3998/ark.5550190.0005.529
Full Text: PDF (296K)
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pp. 334 - 348
received Feb 2 2004; accepted Apr 26 2004; published Apr 28 2004;
30. Solid phase synthesis of 5,6-disubstituted pyrimidinone and pyrimidindione derivatives (VT-1072LP)
Maria Cristina Parlato, Claudia Mugnaini, Michela Lucia Renzulli, Federico Corelli and Maurizio Botta
DOI: https://doi.org/10.3998/ark.5550190.0005.530
Full Text: PDF (181K)
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pp. 349 - 363
received Feb 2 2004; accepted May 4 2004; published May 5 2004;
31. Aromatic Schiff bases and 2,3-disubstituted-1,3-thiazolidin-4-one derivatives as antiinflammatory agents (VT-1043LP)
Iana Vazzana, Emanuela Terranova, Francesca Mattioli and Fabio Sparatore
DOI: https://doi.org/10.3998/ark.5550190.0005.531
Full Text: PDF (155K)
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pp. 364 - 374
received Jan 14 2004; accepted May 12 2004; published May 16 2004;
32. Dynamic kinetic resolution of alpha-bromoesters containing lactamides as chiral auxiliaries (VT-1091LP)
Alessandra Ammazzalorso, Rosa Amoroso, Giancarlo Bettoni, Barbara De Filippis, Letizia Giampietro, Cristina Maccallini, Maria Luisa Tricca
DOI: https://doi.org/10.3998/ark.5550190.0005.532
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pp. 375 - 381
received Dec 31 2003; accepted May 12 2004; published May 16 2004;
33. A step further in the discovery of phthalein derivatives as Thymidylate Synthase inhibitors (VT-1052LP)
Samuele Calò, Donatella Tondi, Alberto Venturelli, Stefania Ferrari, Piergiorgio Pecorari, Marcella Rinaldi, Stefano Ghelli and M. Paola Costi
DOI: https://doi.org/10.3998/ark.5550190.0005.533
Full Text: PDF (197K)
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pp. 382 - 396
received Jan 30 2004; accepted May 27 2004; published May 28 2004;


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